Regional venous-to-arterial carbon dioxide pressure and content differences during endotoxemic shock: influence of hydrogen ion accumulation vs. Haldane effect.

ABSTRACT:

Background

The relationship between carbon dioxide pressures (PCO₂) and contents (CCO₂) is linked to the Haldane effect. Nevertheless, under shock conditions, hydrogen ion accumulation might strongly influence the discrepancies between PCO₂ and CCO₂. This study aims to evaluate the impact of hydrogen ion accumulation and hemoglobin oxygen saturation (Haldane effect) on PCO₂:CCO₂ relationships during induction and resuscitation of endotoxemic shock.

Methods

Shock was induced by an escalating dose of lipopolysaccharide in 12 female Landrace pigs. Norepinephrine was then started to maintain mean arterial pressure ≥ 75 mmHg, while successive fluid boluses were administered targeting arterial lactate < 2.0 mmol·L

SUBMITTER: Ospina-Tascon GA 

PROVIDER: S-EPMC12417345 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature