The hydrogenation side-reaction in copper-mediated radiofluorination.

ABSTRACT:

Background

Copper-mediated radiofluorination (CMRF) is a breakthrough in ¹⁸F-radiochemistry, enabling ¹⁸F incorporation into molecules even at electron-rich aromatic positions. In recent years, several improved protocols have been reported to advance the application of CMRF. These advancements primarily focus on improving radiochemical conversion, expanding substrate scope, and enabling scalability for remote-controlled radiotracer production. Despite these improvements, one major challenge remains: the protodemetallation. Protodemetallation is a common side reaction in transition metal-mediated cross-couplings that takes place by a mechanism that is not yet fully elucidated. In ¹⁸F-chemistry, the formation of the hydrogenated side product (HSP) can

SUBMITTER: Kaur S 

PROVIDER: S-EPMC12417351 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature