The association of fluid balance with traumatic brain injury outcomes: A systematic review.

ABSTRACT:

Background

Fluid balance management is critical in moderate and severe traumatic brain injury (TBI) due to impaired cerebrovascular autoregulation. This study systematically reviews the association of fluid volume management with outcomes in moderate to severe TBI.

Methods

We conducted a systematic literature search on MEDLINE, EMBASE, CINAHL, The Cochrane Database, and bibliographies of included articles. Studies assessing fluid volume management and outcomes in moderate/severe TBI patients were included. Risk of bias, publication bias, and heterogeneity were comprehensively assessed. Primary outcomes were short/long-term mortality and neurological outcomes. Secondary outcomes included the effect on intracranial pressure, development of acute kidney injury (AKI), refractory

SUBMITTER: Kalakoutas A 

PROVIDER: S-EPMC12417381 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature