Impact of antidote quantity, timing and prehospital strategies in nerve agent mass casualty events: a simulation study.

ABSTRACT:

Introduction

Mass casualty incidents (MCIs) involving nerve agents pose major challenges for emergency medical response due to rapid symptom onset, hazardous environments, and operational uncertainties. Several gaps remain in the knowledge about the prehospital response to nerve agent MCI treatment strategies and logistical decision-making. To address these gaps, this study uses Discrete Event Simulation to evaluate the impact of advanced medical stabilization (AMS) team arrival time, antidote availability, and evacuation policy on patient survival during an urban chemical-traumatic MCI with a subway sarin release scenario.

Methods

A validated simulation model (SIMEDIS) was adapted to represent the full prehospital response chain, including triage, antidote administration, A

SUBMITTER: De Rouck R 

PROVIDER: S-EPMC12417396 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature