Longitudinal imaging evaluation of the inflammatory role of purinergic A₂A receptors during subacute and chronic ischemic stroke.

ABSTRACT: Adenosine A₂ receptors (A₂ARs) have shown promising therapeutic properties despite their controversial role in modulating stroke outcome. However, the temporal evolution of cerebral A₂ARs density after cerebral ischemia and its subsequent neuroinflammatory response have been scarcely explored. In this study, the expression of A₂ARs after transient middle cerebral artery occlusion (MCAO) was evaluated in rats by positron emission tomography (PET) with [¹¹C]SCH442416 and immunohistochemistry (IHC). In addition, the role of A₂ARs in stroke inflammation with pharmacological modulation was assessed with magnetic resonance imaging (MRI), PET imaging with [¹⁸F]DPA-714 (TSPO), IHC, western-blot, and autoradiography. After

SUBMITTER: Garbizu M 

PROVIDER: S-EPMC12417452 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature