Deep behavioral phenotyping tracks functional recovery following tibia fracture in mice.

ABSTRACT:

Introduction

An estimated 178 million fractures occur worldwide annually, with lower limb fractures showing high rates of poor healing, often resulting in reduced mobility and chronic pain. Bone healing and the ability to bear weight are closely tied to the mechanical stability of the fracture site. Although fracture stabilization is a well-established factor modulating bone repair, there remains a notable gap in sophisticated non-destructive technologies that can rapidly and objectively quantify functional recovery in preclinical settings. We introduce a novel behavioral phenotyping approach enabling rapid quantification of post-fracture weightbearing and kinematic metrics in freely behaving mice. Our goals were to identify and characterize metrics most indicative of fracture-indu

SUBMITTER: Layne JE 

PROVIDER: S-EPMC12417503 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature