Correlation between metformin use and mortality in acute respiratory failure: a retrospective ICU cohort study.

ABSTRACT:

Background

The aim of this study was to investigate the association of metformin use with the risk of in-hospital mortality and prognosis in acute respiratory failure (ARF) patients admitted to the intensive care unit (ICU).

Methods

We conducted a retrospective cohort study using the MIMIC-IV database. Patients were categorized into metformin and non-metformin groups based on medication exposure. Primary outcomes were in-hospital and ICU mortality, while 30-day and 90-day all-cause mortality served as secondary endpoints. We applied Kaplan-Meier survival curves, Cox proportional hazards models, and logistic regression to assess associations. Propensity score matching (PSM) and machine learning algorithms were used for confounder adjustment and feature selection.

Results</

SUBMITTER: Yang Y 

PROVIDER: S-EPMC12417518 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature