Effect of psilocybin therapy on suicidal ideation, attempts, and deaths in people with psychiatric diagnoses: a systematic review and meta-analysis.

ABSTRACT:

Background

Suicidal ideation, attempts, and deaths present a major and tragic public health concern. Recent trials of psilocybin therapy (PT) have shown promise in treating treatment-resistant depression and have found a reduction in suicidal ideation. Given the growth of PT research, there is a need to further understand its effect on suicidal ideation, attempts, and deaths.

Objective

To assess and synthesize evidence on the effects of PT on suicidal ideation, attempts, and deaths in psychiatric patients.

Design

PRISMA-compliant systematic review and meta-analysis.

Data source

MEDLINE, EMBASE, Cochrane, and PsychINFO.

Method

Databases were searched for randomized controlled trials of PT in adults with psychiatric diagnoses that reported suicide outcomes

SUBMITTER: Wong S 

PROVIDER: S-EPMC12417673 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature