Improving the efficacy of late-line immunotherapy for advanced esophageal cancer: the addition of local radiotherapy.

ABSTRACT:

Background

The advent of immunotherapy has significantly revolutionized therapies for advanced esophageal cancer (EC). However, clinical data on combining immune checkpoint inhibitors (ICIs) and radiotherapy (RT) in advanced EC remain insufficient.

Objectives

This study aimed to evaluate the effectiveness and safety of combining immunotherapy and radiation as a second or subsequent line of treatment for advanced EC.

Design and methods

We retrospectively analyzed patients with advanced EC who received late-line ICIs and categorized them into two subgroups based on whether they received RT. The differences in survival and adverse events (AEs) were evaluated. Inverse probability of treatment weighting (IPTW) and 1:1 propensity-score matching (PSM) analysis were used to m

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12417674 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature