Association between farm-level antimicrobial usage and antimicrobial resistance in Escherichia coli isolates from healthy swine in ten farms in Japan.

ABSTRACT: We examined the antimicrobial resistance of 1,493 Escherichia coli isolates from 440 swine fecal samples (211 and 229 samples were obtained from the sow and fattening groups, respectively) on ten farms and analyzed the association between the antimicrobial resistance rate and the annual antimicrobial usage at the farm level adjusted by the daily defined dose in Japan. For most antimicrobial agents, the rate of resistance was greater on farms with higher levels of antimicrobial use, suggesting that the amount of the corresponding antimicrobial class used at the farm level may have affected the resistance rates. Some antimicrobial resistance was positively associated with the use of the corresponding or structurally related antimicrobial agents: resistance to tetracycline in the sow group an

SUBMITTER: Tamamura-Andoh Y 

PROVIDER: S-EPMC12417727 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature