Investigation on the Influence of Protein Corona and Platelet Adhesion on Storage Bag Surface on the Platelet Storage Lesion.

ABSTRACT: Platelet transfusion is an indispensable therapy used in contexts ranging from hemorrhagic bleeding to chemotherapy. However, platelet shelf life and quality deteriorate during storage in a process termed the platelet storage lesion (PSL), resulting in chronic shortages globally. The PSL is thought to be partially attributed to the bio-incompatible polyvinyl chloride (PVC) storage bags that promote protein fouling and platelet adhesion. Developing platelet-friendly materials is therefore essential for improving platelet storage quality. This study aimed to delineate the contributions of protein adsorption and platelet adhesion to the progression of the PSL. Hydrophilic coatings are screened to identify those which resist protein and platelet adhesion most effectively. These coatings are tr

SUBMITTER: Pereyra N 

PROVIDER: S-EPMC12417748 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature