PLUS: Primary Layer for Universal Sensing Enabling Improved Immunocapture of Biomarkers in Clinical Scenarios.

ABSTRACT: The biofunctionalization of sensor surfaces to enable biorecognition capabilities remains a major challenge in developing diagnostic devices. However, efficient surface chemistries applicable to various sensor types remain elusive. In this study, Primary Layer for Universal Sensing (PLUS), a universal coating for bioprobe immobilization designed to enhance sensor functionality across diverse substrates, is introduced. Derived from the mussel-inspired, catechol-based adhesive polydopamine (pDA), PLUS ensures material-independent coating ability. Unlike conventional methods that involve secondary bioprobe immobilization onto a pre-formed pDA layer, PLUS is directly grown from dopamine (DA) and avidin proteins as co-polymerization precursors, resulting in a highly roughened surface with abund

SUBMITTER: Son N 

PROVIDER: S-EPMC12417755 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature