Deep Dive into the Cardio-Pulmonary-Renal Interactions in Patients with Pulmonary Hypertension: Serum Creatinine Levels Even Within the Normal Range Related to Long-Term Survival.

ABSTRACT:

Background

Renal function in patients with pulmonary hypertension (PH) can be disrupted due to hypotension, low cardiac output, and venous pressure overload because of the its dependency on the pressure gradient between systemic arterial and venous circulations. The aim was to investigate whether measures of venous and pulmonary circulations determine renal function in patients with PH.

Methods

The single-center study group comprised 1071 patients with a hemodynamically confirmed PH diagnosis. Serum creatinine level was used for surrogate of renal perfusion status. Echocardiographic measures included left ventricle ejection fraction (LVEF), tricuspid annular plane excursion (TAPSE), and right atrial area (RAA). Hemodynamic parameters included mean aortic and pulmonary pressu

SUBMITTER: Tokgoz HC 

PROVIDER: S-EPMC12417885 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature