Visible Light-Induced Pigmentation: Improved In Vivo Methodology for Measuring Efficacy of 30 Products in 9 Randomised Controlled Trials and Correlation With In Vitro Assessment.

ABSTRACT: As hyperpigmentation can worsen with exposure to ultraviolet (UV) and visible light (VL), sunscreens with well-balanced UVB/UVA protection and VL-blocking pigments are recommended. Assessing efficiency against VL-induced pigmentation is then mandatory. Recently, an in vivo pigmentation assessment allowing a VL protection factor (pVL-PF) determination, and an in vitro predictive method based on transmittance measures were introduced. However, the number of volunteers, tested sunscreens, and protection range were limited. Moreover, no statistical assessment was associated. This study aimed at testing the robustness and improving these methodologies by conducting a series of 9 monocentric, double-blind, randomised controlled in vivo studies involving 188 volunteers and 30 products, alongside

SUBMITTER: Renoux P 

PROVIDER: S-EPMC12417931 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature