Impact of anterior callosal disconnection on picture naming in frontal lobe epilepsy surgery.

ABSTRACT: Epilepsy surgery in focal, drug-resistant frontal lobe epilepsy can be curative and resection is aimed at seizure freedom. The cognitive impact of surgery, however, is less clear-cut. On one hand, resection of the epileptogenic zone can disconnect essential brain networks and therefore cause dysfunction. On the other hand, surgery may prompt recovery of normal brain function by restoring normal electrical activity as propagating epileptic discharges affect cognition outside the epileptogenic zone. To understand the impact of surgery on cognitive outcome, we investigated picture naming in 51 patients undergoing frontal lobe epilepsy surgery (28 left-hemisphere-dominant; 23 language-dominant) preoperatively and at 12 months follow-up using complementary voxel-based lesion symptom mapping, tr

SUBMITTER: Giampiccolo D 

PROVIDER: S-EPMC12417999 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature