An Indirect Comparison of Diagnostic Accuracy for Seven Different SARS-CoV-2 Serological Assays: A Meta-Analysis and Adjusted Indirect Comparison of Diagnostic Test Accuracy.

ABSTRACT:

Objectives

This study compared the diagnostic accuracy of seven different commercial serological assays for COVID-19, using RT-PCR as the gold standard, through meta-analysis and indirect comparison.

Methods

Fifty-seven studies, published from November 2019 to June 2024, were included. The diagnostic performance of IgA, IgG, and total antibody assays for SARS-CoV-2 was assessed. The netmeta, rjags, and gemtc packages in R software were used for adjusted indirect comparison to calculate the relative diagnostic odds ratio (RDOR).

Results

The pooled diagnostic odds ratio (DOR) for Abbott SARS-CoV-2 IgG was 542.81, for Elecsys Anti-SARS-CoV-2 N was 1022.34, for Elecsys Anti-SARS-CoV-2 total was 1701.56, for Euroimmun Anti-SARS-CoV-2 IgA was 45.91, for Euroimmun Anti-SARS-

SUBMITTER: Zhang M 

PROVIDER: S-EPMC12418076 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature