Carbapenemase-Producing <i>Enterobacteriaceae</i> Colonization and the Risk of Carbapenemase-Producing <i>Enterobacteriaceae</i> Bacteremia in Hematopoietic Stem Cell Transplant Recipients.

ABSTRACT:

Background

Carbapenemase-producing Enterobacteriaceae (CPE) are globally concerning pathogens due to limited therapeutic options. Despite the increasing incidence of CPE infections, evidence supporting effective empirical treatments for individuals undergoing hematopoietic stem cell transplantation (HSCT) remains limited.

Methods

From January 2019 to December 2023, individuals undergoing HSCT screened for CPE colonization via perianal swabs upon admission before HSCT were retrospectively analyzed. Culture-based identification and carbapenemase-specific polymerase chain reaction were performed. The occurrence of Enterobacteriaceae bacteremia within 100 days post-HSCT was monitored. Propensity-score (PS) matching and competing risk analyses were used to evaluate

SUBMITTER: Kang SW 

PROVIDER: S-EPMC12418090 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature