Intermittent theta burst stimulation enhances prefrontal activation and connectivity: evidence from fNIRS.

ABSTRACT:

Objective

To investigate the neuro-regulatory mechanisms of intermittent theta burst stimulation (iTBS) on prefrontal brain function.

Methods

Functional near-infrared spectroscopy (fNIRS) was used to monitor the blood flow dynamics response in the prefrontal cortex of 20 healthy adults. Measurements were taken at five time points (10, 25, 40, 55, and 70 min) after iTBS stimulation, as well as before stimulation (T0). The activation intensity of prefrontal cortex was assessed by quantifying the relative change in oxygenated hemoglobin concentration (β value), and functional connectivity between prefrontal-related brain regions was evaluated by calculating the correlation coefficients of oxygenated hemoglobin concentration between channels across time series for each subject.<

SUBMITTER: Zhao YN 

PROVIDER: S-EPMC12418203 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature