Adherence of Anti-Dementia Medications in Alzheimer's Disease and Related Dementia: A Nationwide Cohort Study in Korea.

ABSTRACT:

Background

Readily available treatments for Alzheimer's disease and related dementia (ADRD) include acetylcholinesterase inhibitors and N-methyl-D-aspartate receptor antagonists. Non-adherence and early discontinuation of anti-dementia medications are prevalent issues. We aimed to investigate factors associated with suboptimal usage of anti-dementia medications in ADRD.

Methods

Based on data extracted from a claim database in South Korea, 508,958 patients with ADRD who began taking anti-dementia medication between 2018 and 2020 were included. The mean possession ratio is the ratio of the sum of prescribed medication supply over one year and non-adherence is defined as mean possession ratio < 80%. Discontinuation is defined as no prescription of anti-dementia medications, or

SUBMITTER: Lee E 

PROVIDER: S-EPMC12418206 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature