Combined minimally invasive vagal cranial nerve and trigeminocervical complex peripheral nerve stimulation produces prolonged improvement of severe painful peripheral neuropathy and hyperglycemia in type 2 diabetes.

ABSTRACT:

Introduction

Diabetic Peripheral Neuropathy (DPN), a debilitating complication of type 2 diabetes mellitus (T2DM), stems from bioenergetic failure and reduced vascular endothelial growth factor-A expression (VEGF-A), persisting despite optimal glycemic control. The meteoric rise of "diabesity"-the coexistence of obesity and T2DM-underscores the ongoing failure of symptom control strategies and the critical need to immediately address the root cause of metabolic dysfunction and neuropathic pain.

Methods

An analysis was performed on patients who received combined minimally invasive auricular vagus cranial nerve stimulation (aVNS) and trigeminocervical complex (TCC) peripheral nerve stimulation in 83 Native American patients (91 initial, 8 lost to follow-up) with severe T2DM an

SUBMITTER: Staats PS 

PROVIDER: S-EPMC12418259 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature