Mapping the distribution of neurotransmitters to resting-state functional connectivity in Parkinson's disease.

ABSTRACT: Dopamine and serotonin are two major monoamine neurotransmitters associated with Parkinson's disease (PD), but their spatial distribution and relationship to underlying functional brain architecture are not fully understood. We assessed 30 patients with PD at baseline using structural MRI, resting-state functional MRI (rs-fMRI), ¹¹C-PE2I and ¹¹C-DASB PET, along with comprehensive clinical evaluations of motor and non-motor symptoms. Of these, 15 patients with PD who completed the same assessments after 19 months were included in the longitudinal analysis. rs-fMRI was used to assess functional connectivity, while ¹¹C-PE2I and ¹¹C-DASB PET were used to evaluate interregional homogeneity of dopamine and serotonin levels, referred to as PET covarianc

SUBMITTER: Li W 

PROVIDER: S-EPMC12418387 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature