Development of Photocurable NorHA-dECM Hybrid Hydrogels to Study Cell-Matrix Interactions.

ABSTRACT: Biomimetic culture platforms aid in understanding cell behavior in vitro and are useful for studying mechanisms of disease progression and tissue regeneration. Synthetic hydrogels are widely used for this purpose, but while they offer advantages such as tunability and mechanical stability, they lack the range of biochemical signals present in the native microenvironment. On the other hand, decellularized extracellular matrices (dECMs) retain native biochemical signals but their adoption as stable in vitro culture platforms is limited due to batch variability, poor mechanical stability, and limited tunability. Here we report the development of hybrid hydrogels comprising dECM and a photocurable norbornene-modified hyaluronic acid (NorHA) polymer. To overcome structural heterog

SUBMITTER: Marjan T 

PROVIDER: S-EPMC12418418 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature