Prolonged exposure to leisure screen time notably accelerates biological aging: Evidence from observational studies and genetic associations.

ABSTRACT: LST is steadily increasing and is associated with various health issues. However, its impact on aging remains unclear. A total of 7212 participants from NHANES 1999-2002 were included. LTL, ALM, and FI were selected as aging phenotypes. Observational association between LST and aging traits was analyzed using linear regression models. MR analyses based on 112 genetic variants were performed to test the causal estimates from LST on aging. TWAS and PPI analyses were conducted to investigate underlying biological mechanisms. After adjusting for physical activity, per 1 ​h increase in LST, participants had a shorter LTL (β ​= ​-1.39, 95 ​% CI: -2.47 to -0.30), a lower ALM (β ​= ​-1.09, 95 ​% CI: -1.39 to -0.70), and an increased FI (β ​= ​8.22, 95 ​% CI: 4.29 to 12.30). Likewise, TSMR analyses

SUBMITTER: Wen J 

PROVIDER: S-EPMC12418421 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature