Concurrent TMS-EEG to characterize cortical responses in the motor and prefrontal cortices in Parkinson's disease.

ABSTRACT: Patients with Parkinson's disease (PD) experience both motor and non-motor symptoms. However, it remains unclear the full spectrum of PD, which requires a comprehensive assessment of both motor and non-motor cortical regions. The use of combined transcranial magnetic stimulation and electroencephalography (TMS-EEG) allows the examination of neural circuit beyond motor cortex. In this study, TMS-EEG data were collected over the primary motor cortex (M1) and dorsolateral prefrontal cortex (DLPFC) in 46 patients with PD and 27 healthy controls (HC). We analyzed TMS-evoked potentials and oscillatory powers to identify differences in cortical excitability and neural connectivity dynamics between the two cohorts. Patients with PD exhibited higher P30 amplitude following M1 stimulation compared t

SUBMITTER: Zhu L 

PROVIDER: S-EPMC12418433 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature