Characterization of responders to transcranial direct current stimulation in disorders of consciousness: A retrospective study of 8 clinical trials.

ABSTRACT: The treatment for patients with disorders of consciousness challenges researchers and clinicians. The stimulation of the left dorsolateral prefrontal cortex with transcranial direct current stimulation (tDCS) may enhance behavioral responsiveness of a subset of patients in a minimally conscious state, while having limited effects in unresponsive patients. However, heterogeneity in responses raises questions about the effectiveness of tDCS. Our objective was to explore the characteristics of responders to tDCS based on previously published RCTs and investigate the heterogeneity of treatment effect to better direct future tDCS studies towards patient profiles that appear to be more responsive to the treatment. We explored clinical and demographical differences between responders (i.e., recov

SUBMITTER: Barra A 

PROVIDER: S-EPMC12418444 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature