Asymmetric Total Synthesis of Leptosphin C.

ABSTRACT: A concise enantioselective total synthesis of leptosphine C (1) has been achieved. Our synthetic strategy features an unprecedented diastereo-/enantioselective Hajos-Parrish-Eder-Sauer-Wiechert (HPESW) reaction for construction of the AB ring system with continuous stereogenic centers (76% yield, 90% ee, dr = 19:1) and an uncommon Pauson-Khand (PK) reaction of geminal dimethyl alkenyl side chains for establishing the CD ring system with the quaternary carbon at C14.

SUBMITTER: Sun L 

PROVIDER: S-EPMC12418496 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature