Taurine as a Protective Metabolite in Radiation-Induced Liver Disease: Evidence from ¹H NMR Metabolomics.

ABSTRACT: Radiation therapy for liver and upper abdominal malignancies is associated with a high risk of radiation-induced liver disease (RILD), often involving metabolic disturbances. This study aimed to characterize metabolomic alterations in a murine RILD model using ¹H-nuclear magnetic resonance (NMR) spectroscopy. RILD was induced in mice via 15 Gy hepatic irradiation. Liver tissues were subjected to time-course metabolomic profiling using ¹H NMR. Validation was performed through liver enzyme assays, histological analysis, and qPCR. Taurine was selected for therapeutic evaluation based on metabolomic findings. Significant reductions in glutathione and pyruvate levels were observed in the acute stage, whereas increases in phenylalanine and tyrosine levels were observed in t

SUBMITTER: Chung YH 

PROVIDER: S-EPMC12418501 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature