Tuning the surface chemistry of NHC-protected Au₁₃ nanoclusters <i>via</i> a robust amide coupling procedure.

ABSTRACT: There is significant potential use for gold nanoclusters in biomedicine owing to their favorable biological and optical properties. To access this potential, there is a need for methods to alter the ligand scaffold of gold nanoclusters to tune their biological properties. Surface modifications to the ligands must occur with molecular precision to generate monodisperse products for the accurate determination of structure activity relationships and eventual translation to clinical practice. Herein, we describe methods for molecularly precise surface modifications to Au₁₃ nanoclusters via amide couplings to -COOH functionalities and their stability to conditions necessary for the removal of protecting groups used in amide coupling chemistry. These clusters were found to be h

SUBMITTER: Laluk ALDM 

PROVIDER: S-EPMC12418512 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature