Muscle MRI quantifies disease progression in amyotrophic lateral sclerosis.

ABSTRACT:

Background and objectives

Quantitative and operator-independent biomarkers of disease progression are urgently needed in amyotrophic lateral sclerosis (ALS) research. We assess the potential of skeletal muscle MRI as a sensitive and reliable outcome measure for future ALS clinical trials.

Methods

In this longitudinal cohort study, muscle MRI of head-neck, upper and lower limb regions, alongside clinical and functional assessments, were acquired at three time points over the individual maximum observation period (iMOP) of 1 year in 20 patients with ALS and 16 healthy controls. Quantitative MRI parameters cross-sectional area (CSA), volume (VOL), fat fraction, functional rest muscle area and water T2 (T_2m) were correlated with changes in clinical disease severity (f

SUBMITTER: Klickovic U 

PROVIDER: S-EPMC12418527 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature