Precision risk stratification of primary gastric cancer after eradication of <i>H. pylori</i> by a DNA methylation marker: a multicentre prospective study.

ABSTRACT:

Background

Precision cancer risk stratification for gastric cancer is urgently needed for the growing number of healthy people after Helicobacter pylori eradication. The epimutation burden in non-malignant tissues has been associated with cancer risk in multiple cross-sectional studies.

Objective

To confirm the clinical usefulness of a DNA methylation marker for epimutation burden, and to identify a cut-off methylation level for a super-high-risk population.

Design

Healthy people after H. pylori eradication with open-type atrophy were prospectively recruited. DNA methylation levels of a marker gene, RIMS1, were measured in biopsy specimens from gastric antrum and body. The primary endpoint was the incidence rate of gastric cancer in quartiles of t

SUBMITTER: Yamada H 

PROVIDER: S-EPMC12418579 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature