Virulence factors and outcomes in bacteremia caused by extended-spectrum β-lactamase-producing uropathogenic Escherichia coli ST131-H30Rx in a Swedish county.

ABSTRACT:

Background

Escherichia coli ST131 and clade H30Rx are the most prevalent extended-spectrum β-lactamase-producing E. coli (ESBL-EC) causing bacteremia and urinary tract infections globally and in Sweden. Previous studies have linked ST131-H30Rx with septic shock and mortality, as well as prolonged carriage. In our previous study, ST131 constituted 54% of all ESBL-EC bacteremia originating from the urinary tract.

Method

Utilizing whole-genome sequencing, we retrospectively compared virulence factors (VFs) and patient outcomes based on medical records among 77 isolates of ESBL-EC from 76 patients with pyelonephritis between 2009 and 2018 in a Swedish county.

Results

The VFs Ibes and uropathogenic specific protein were associated with ST131 of all clades (p < 0.0001). Ser

SUBMITTER: Moller V 

PROVIDER: S-EPMC12418608 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature