Nigral stimulation for freezing of gait: kinematic gait parameters inform optimization of stimulation frequency.

ABSTRACT: Innovative technology allows for personalization of stimulation frequency in dual-site deep brain stimulation (DBS), offering promise for challenging symptoms in advanced Parkinson's disease (PD), particularly freezing of gait (FoG). Early results suggest that combining standard subthalamic nucleus (STN) stimulation with substantia nigra pars reticulata (SNr) stimulation may improve FoG outcomes. However, patient response and the optimal SNr stimulation frequency vary. Our randomized controlled trial studied patients with advanced PD and persistent FoG, while recording gait kinematics through wearable inertial sensors, along with clinical assessments and patient-reported outcomes. In a with-subjects design, we compared a no-stimulation control with four stimulation conditions: Mono-site ST

SUBMITTER: Weiss D 

PROVIDER: S-EPMC12418677 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature