Body muscle mass versus fat mass: gender-specific associations with NAFLD and liver fibrosis.

ABSTRACT:

Background

This study aimed to investigate the gender-specific associations of skeletal muscle mass and fat mass with non-alcoholic fatty liver disease (NAFLD) and NAFLD-related liver fibrosis in two population-based studies.

Methods

Analyses were based on data from the MEGA (n = 238) and the MEIA study (n = 594) conducted between 2018 and 2023 in Augsburg, Germany. Bioelectrical impedance analysis was used to evaluate relative skeletal muscle mass (rSM) and SM index (SMI) as well as relative fat mass (rFM) and FM index (FMI); furthermore, the fat-to-muscle ratio was built. The fatty liver index (FLI) was calculated to identify NAFLD. To estimate the degree of liver fibrosis, liver stiffness was assessed in the MEGA study using ultrasound elastography. Multivariable gamma re

SUBMITTER: Volaklis K 

PROVIDER: S-EPMC12418690 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature