Cross-species protection suggests <i>Entamoeba histolytica</i> trogocytosis enables complement resistance through the transfer of negative regulators of complement activation.

ABSTRACT: Entamoeba histolytica is a major cause of diarrheal disease. E. histolytica trophozoites ("amoebae") can invade the intestine and disseminate via the bloodstream, resisting complement lysis through unknown mechanisms. Amoebae kill human cells by performing trogocytosis. After performing trogocytosis, amoebae display human proteins on their own surface and are resistant to lysis by human serum. In this study, we sought to further evaluate the mechanism by which amoebae resist complement lysis. To test if complement is responsible for lysis of amoebae, C3-depleted serum was compared to replete serum, and C3 was indeed required for lysis. Amoebae were allowed to perform trogocytosis of human cells and exposed to mouse serum. Although they had performed trogocytosis on a differen

SUBMITTER: Ruyechan MC 

PROVIDER: S-EPMC12418739 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature