Cervicovaginal microbial features predict <i>Chlamydia trachomatis</i> spread to the upper genital tract of infected women.

ABSTRACT: Chlamydia trachomatis (CT) infection can lead to pelvic inflammatory disease, infertility, and other reproductive sequelae when it ascends to the upper genital tract. Factors including chlamydial burden, coinfection with other sexually transmitted bacterial pathogens, and oral contraceptive use influence risk for upper genital tract spread. Cervicovaginal microbiome composition influences CT susceptibility, and we investigated if it contributes to spread by analyzing amplicon sequence variants (ASVs) derived from the V4 region of 16S rRNA genes in vaginal samples collected from women at high risk for CT infection and for whom endometrial infection had been determined. Participants were classified as CT negative (CT-, n = 70), CT positive at the cervix (Endo-, n = 79),

SUBMITTER: Jeong S 

PROVIDER: S-EPMC12418748 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature