The influence of biological sex on diagnostic markers of acute kidney injury in acute-on-chronic liver failure: insights from a single-centre tertiary care study.

ABSTRACT: Biological sex has a profound impact on disease severity, outcomes and diagnosis yet, its role in clinical disease is insufficiently explored. Acute on chronic liver failure (ACLF) is associated with high mortality and multiple organ dysfunctions, where acute kidney injury (AKI) significantly worsens prognosis. Here we investigated the impact of sex on the diagnostic parameters used for severity grading in ACLF. We enrolled 1,134 ACLF patients, and shortlisted 757 patients (636 males, 121 females) admitted to All India Institute of Medical Sciences, New Delhi, between 2016 and 2023. ACLF-AKI was defined and staged according to International Club of Ascites criteria. The impact of sex on baseline clinical parameters, AKI incidence, and progression were assessed using the statistical tools I

SUBMITTER: Saha R 

PROVIDER: S-EPMC12418795 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature