Feasibility of High-Resolution Deuterium Metabolic Imaging of the Human Kidney Using Concentric Ring Trajectory Sampling at 7T.

ABSTRACT: The human kidneys play a pivotal role in regulating blood pressure, water, and salt homeostasis, but assessment of renal function typically requires invasive methods. Deuterium metabolic imaging (DMI) is a novel, noninvasive technique for mapping tissue-specific uptake and metabolism of deuterium-labeled tracers. This study evaluates the feasibility of renal DMI at 7-Tesla (7T) to track deuterium-labeled tracers with high spatial and temporal resolution, aiming to establish a foundation for potential clinical applications in the noninvasive investigation of renal physiology and pathophysiology. Five healthy participants (3 m/2f) underwent renal DMI at 7T using MR spectroscopic imaging with concentric ring trajectory sampling. Two subjects participated in dynamic DMI experiments after oral

SUBMITTER: Niess F 

PROVIDER: S-EPMC12418914 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature