Cognition before and after psychosis onset: A naturalistic study of change, heterogeneity, and prognosis.

ABSTRACT:

Aims

Cognitive dysfunction is a core feature of psychotic disorders. The degree of impairment varies greatly between individuals, which may reflect different levels of decline from pre-morbid functioning. Diverse trajectories of cognitive change prior to or during development of psychosis have been hypothesized to reflect distinct underlying pathological processes. Our primary aim was to model cognitive change over time in a sample of individuals with first-episode psychosis (FEP) and controls. The secondary aim was to explore associations between cognitive change, clinical outcomes and select biological markers.

Methods

Our sample consisted of 72 individuals with FEP and 53 controls. School grades from nationwide population registers were used as a proxy for pre-morbid cogn

SUBMITTER: Lee M 

PROVIDER: S-EPMC12419124 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature