Comprehensive analysis of mitochondrial energy metabolism-related genes and immune infiltration in intervertebral disk degeneration.

ABSTRACT: Lower back pain caused by intervertebral disk degeneration (IDD) is a common problem among middle-aged and older adults. We aimed to identify novel diagnostic biomarkers of IDD and analyze the potential association between key genes and immune cell infiltration. We screened differentially expressed genes (DEGs) related to IDD and gene sets associated with mitochondrial energy metabolism using the Gene Expression Omnibus and GeneCards databases, respectively. Subsequently, we used multiple enrichment analysis methods to determine the biological functionalities of mitochondrial energy metabolism-related differentially expressed genes (MEMRDEGs). Key genes were selected using logistic regression analysis, a support vector machine algorithm, and least absolute shrinkage and selection operator

SUBMITTER: Lv J 

PROVIDER: S-EPMC12419262 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature