Exploring multiple myeloma pathobiology and immune cell signatures: Evidence from bidirectional genetic analysis.

ABSTRACT: The causal relationship between immune cell signatures and multiple myeloma (MM) pathobiology remains incompletely understood. This study aimed to explore the bidirectional causal associations between 731 circulating immune cell traits and MM risk using a two-sample, bidirectional Mendelian randomization (MR) approach. Two-sample MR analyses were conducted utilizing genome-wide association study (GWAS) summary statistics for 731 immune cell phenotypes and MM GWAS datasets. Sensitivity analyses were performed to assess the robustness and reliability of the findings. Furthermore, meta-analyses were conducted on specific immune cell traits identified through the primary MR analyses to reinforce causal inferences. We identified 11 immune cell traits across 3 immune profiles - absolute cell cou

SUBMITTER: Tian Y 

PROVIDER: S-EPMC12419270 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature