A Mendelian randomization study of serum uric acid in metabolic and cardiovascular risk in East Asian populations.

ABSTRACT: Serum uric acid (SUA) levels are linked to increased disease vulnerability and higher recurrence rates; however, the exact causal relationships are elusive. Despite the prevalent hyperuricemia in East Asian populations, comprehensive research on the intricate association between SUA levels and disease is lacking. To address this, a study utilizing a 2-sample Mendelian randomization (MR) approach was conducted in East Asian populations. This study utilized MR to explore the correlation between SUA levels and various disorders, employing data from genome-wide association studies and multiple independent single-nucleotide polymorphism. Multiple single-nucleotide polymorphisms were applied to assess the causal relationship between SUA and other diseases. Methodologies encompassed inverse-varia

SUBMITTER: Li J 

PROVIDER: S-EPMC12419271 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature