Advanced Glycation End Products Induce Caudal Disc Degeneration in Ovariectomized Female Rats.

ABSTRACT:

Background

Preclinical animal models are indispensable for the development of new therapeutic strategies and the study of the pathological mechanisms of intervertebral disc (IVD) degeneration (IVDD). This study aims to develop a reliable and reproducible rat model of IVDD by injecting advanced glycation end products (AGEs) into the IVD of ovariectomized rats.

Methods

Twenty-eight female Sprague-Dawley rats were allocated into the 31G needle group, vehicle group, 0.5 μg AGEs group, 1 μg AGEs group, 2 μg AGEs group, 4 μg AGEs group, and non-ovariectomy group (n = 4). The coccygeal discs of the 31G needle group were punctured only, while the coccygeal discs of the vehicle group were injected with 1 μL PBS. The coccygeal discs of the AGEs groups underwent injection of AGE

SUBMITTER: Liang X 

PROVIDER: S-EPMC12419273 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature