Causal associations of air pollutants with chest and gingival pain: Genetic insight from Mendelian randomization study.

ABSTRACT: Epidemiological studies have already established associations between air pollutants and adverse health outcomes, but the causal associations between air pollutants and chest pain (CP) and gingival pain (GP) remain unclear. This study aimed to explore the potential causal effects of air pollutants on CP and GP. Utilizing genome-wide association study summary statistics from European-ancestry populations, we conducted bidirectional two-sample Mendelian randomization (MR) analyses. Causal estimates were primarily derived through inverse-variance weighted regression, weighted median, MR-Egger, and weighted mode methods to assess pleiotropy and robustness. Multivariable MR (MVMR) further adjusted for smoking and alcohol consumption covariates. MR analyses demonstrated significant causal effect

SUBMITTER: Xiao XP 

PROVIDER: S-EPMC12419278 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature