Genetic evidence for causal associations between common cell-derived signaling molecules and sleep disorders and the mediating role of metabolites.

ABSTRACT: Although the potential causal associations between cell-derived signaling molecules and sleep disorder (SD) have been reported, contradictions remain. This study assessed the causal effects and the mediating role of 1400 metabolites among 91 cell-derived signaling molecules and SD from a genetic perspective by performing Mendelian randomization (MR) analyses. Genetic instruments derived from publicly available genome-wide association studies were employed in this study, including 49,880 SD cases and 358,194 controls. Summary statistics of 1400 circulating metabolites were obtained from a cohort of 8299 individuals. The 91 cell-derived signaling molecules were derived from genome-wide association studies data from 11 cohorts comprising 14,824 samples. Multiple statistical analyses were intr

SUBMITTER: Li L 

PROVIDER: S-EPMC12419301 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature