Investigating bidirectional causality between prostate cancer and inflammatory factors: A 2-sample Mendelian randomization analysis.

ABSTRACT: Growing evidence have indicated the bidirectional relationships between various inflammatory cytokines and prostate cancer (PCa), but the causality between genetic susceptibility to inflammatory cytokines and PCa was still in initial exploratory phase. This bidirectional Mendelian randomization (MR) research was manipulated to draw causative inferences and the effect of direction between 91 inflammatory cytokines and PCa. Genetic data of PCa were originated from a publicly accessible genome-wide association study with 3269 individuals and 459,664 controls, and inflammatory cytokines summarized by a protein quantitative trait locus study were embodied 14,824 participants. We considered inverse variance weighted as a primarily statistical approach, and utilized MR-Egger regression, weighted

SUBMITTER: Wang J 

PROVIDER: S-EPMC12419315 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature