Integration of summary data from GWAS and eQTLs studies predicts causality of S1PR1 and breast cancer.

ABSTRACT: Breast cancer is a major health threat to women, with limited effective indicators for early screening and prognosis. The role of sphingosine 1-phosphate receptor 1 (S1PR1) in breast cancer remains controversial. This study aims to explore the potential causal relationship between S1PR1 and breast cancer risk, considering estrogen receptor (ER) status. Summary-level data for genome-wide association studies (GWAS) and expression quantitative trait loci (eQTLs) from European ancestry was collected. A summary-data-based Mendelian randomization (SMR), multi-SNP-based SMR, heterogeneity in dependent instruments (HEIDI) test, 2-sample MR analysis, and Bayesian colocalization method were conducted. Potential targets for S1PR1 were predicted based on DrugBank and ChEMBL databases. Elevated S1PR1 e

SUBMITTER: Shi H 

PROVIDER: S-EPMC12419331 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature