Causality between thyroid disease and psoriasis: Bidirectional Mendelian randomization analysis.

ABSTRACT: Both psoriasis and autoimmune thyroid diseases are characterized by chronic inflammation. The previous studies indicated a potential association between psoriasis and autoimmune thyroid diseases. However, the direction and nature of these relationships remain unclear. This study aimed to investigate the bidirectional causal relationships between multiple thyroid diseases (hypothyroidism, hyperthyroidism, Hashimoto thyroiditis, and Graves disease (GD)) and psoriasis (PsO) as well as its subtypes (psoriasis vulgaris (PV) and psoriatic arthritis (PsA)) through a two-sample Mendelian randomization (MR) approach. A bidirectional, two-sample MR analysis was conducted using genome-wide association study (GWAS) summary statistics from large European populations. Independent single nucleotide polym

SUBMITTER: Cong X 

PROVIDER: S-EPMC12419343 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature