Bidirectional Mendelian randomization study reveals causal relationships between polymyalgia rheumatica and serum metabolites.

ABSTRACT: Polymyalgia rheumatica (PMR) is a prevalent chronic inflammatory disorder among the elderly, presenting diagnostic and therapeutic challenges. Existing treatments like glucocorticoids have significant side effects, and the molecular mechanisms of PMR remain unclear. This study employed a 2-sample bidirectional Mendelian randomization approach to explore the causal relationship between 1091 metabolites, 309 metabolite ratios, and PMR risk. genome-wide association study data from large-scale cohorts were utilized, including metabolite data from 8299 Europeans and PMR datasets from FinnGen R12. After identifying suitable genetic instrumental variables and conducting multiple statistical analyses, 13 metabolites were found to be significantly associated with PMR risk at a P <.05 significance l

SUBMITTER: Song A 

PROVIDER: S-EPMC12419372 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature