Are lipid-lowering drugs harmful to cognitive performance?: A Mendelian randomization study.

ABSTRACT: Cardiovascular disease is the leading global cause of mortality, affecting the development of cognitive impairment in the elderly. Lipid-lowering drugs are commonly used to manage cardiovascular disease risk, but their effects on cognitive performance have produced conflicting results in previous research. To better guide the selective decision-making and application of lipid-lowering drugs, this study aims to determine the causal relationship between lipid-lowering drugs and cognitive performance through Mendelian randomization. We conducted a 2-sample Mendelian randomization study based on summary statistics from genome-wide association studies for lipid-lowering drugs and cognitive performance. Single-nucleotide polymorphisms significantly related to low-density lipoprotein cholesterol

SUBMITTER: Han L 

PROVIDER: S-EPMC12419384 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature