Complex causal association between immune cells and psoriatic arthritis: A bidirectional Mendelian randomization study.

ABSTRACT: Previous epidemiological research has shown that immune cells have a significant impact on the progression and development of psoriatic arthritis (PsA). However, the causal relationship between immune cell characteristics and PsA remains uncertain. A bidirectional 2-sample Mendelian randomization analysis was conducted, using data from publicly available genome-wide association studies. Four Mendelian randomization analysis methods were employed to assess the causal relationships between 731 immunological traits and PsA, with the inverse variance weighted method as the primary analysis. Multiple sensitivity analyses were carried out to confirm the reliability of the findings. After false discovery rate (FDR) adjustment, the genetically predicted inverse variance weighted methods revealed t

SUBMITTER: Jia Y 

PROVIDER: S-EPMC12419392 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature